Jobelli takes us on "a journey that's spanned the globe and brought with it a kaleidoscope of blind alleys, high hopes and stark tragedy," in his efforts to trace the history of human interaction with Alzheimer's dementia. He takes us from the discovery of the malady to the frontiers of the science trying to combat it, whether through lifestyle changes or through novel approaches to clearing out-of-control amyloid from the brain by gene therapy, blood transfusions, and even the surprising potency of tumeric. Hope might come from research into communities as far-flung as Iceland and Columbia. he concludes from the best of science at the end of 2017 that the disease is age-related, though aging not itself the cause, and that genetics and earlier detection are apparently the keys to our next successes. He sees blessed hope through many strains of research that we will see the "abolition" of this epidemic.